Call for Take-Out: 850-215-4562

Enzo's Pizza and Grill, located in the heart of the Historic St. Andrews district in Panama City, offers a delectable choice of Italian fare and more.

Opened in 2010, Enzo's is the 2014 and 2016 winner of the Reader's Choice Award for Best Pizza in Panama City by Panama City Living Magazine and Enzo's is consistently in the Top 10 for Best of Bay for our pizza and wings.

For Take Out: Call 850-215-4562


Payton K.

“This is my absolute favorite place to eat!! No matter what I've tried, it is all extremely good. From the pizzas to the chicken sandwich on the menu. Dessert is amazing, appetizers are perfect! There was a problem with staff a while back but the issue has since been fixed and everyone should know that you will have a pleasant experience! I visit frequently and have never been disappointed, even if staff disappointed, the food never did. Thanks Enzo's!!!”

Gina G.

“We were looking for deep dish and after reading the reviews we had to give it a try. When we drove up my fiancé was a little skeptical, but I was adamant that some of the best spots are the small, local joints. We ventured in and were greeted by smiling, friendly faces. We sat out on the covered porch and ordered drinks and a small house salad to share. One small deep dish was plenty, but only gave us two slices for the next day (should have ordered a large for leftovers!). LOVE THE DEEP DISH. The crust was perfect and the pep, mush, onion pizza was spot on, the chef gave equal distribution to all toppings! Love this place!”

Carlton C.

“Great service and amazing food. The tiramisu was fresh and moist. The flavors were not over whelming. Great place”

Keith P.

“GET HERE NOW! And when you get here, get the double decker pizza! It's awesome! Sitting outside has been really nice, it's 83 degrees, and the service has been really good. Good atmosphere and excellent pizza. Super. Finally a great place to eat around here. Easily one of the top 3 pizza's that I've ever eaten (as a pilot, I've been everywhere and have eaten many a pizza).”


  • Enzos Pizza and Grill

    Enzo's Pizza and Grill, located in Historic St. Andrews, offers homemade doughs, dressings, sauces, soup and lasagna made fresh daily. We offer Thin Crust Pizza, Chicago Deep Dish Pizza and Double Decker Pizza. In addition, traditional Italian entrees such as Chicken Parmesan, Fettucine Alfredo and Manicotti, to name a few, are offered. Fresh subs, salads and jumbo buffalo wings are staples here at Enzo's.

  • Enzos Pizza and Grill

    Our dough, sauces, soups and dressings are all homemade. You can choose from our Chicago style thin crust pizza, Chicago deep dish pizza or our Double Decker Pizza, all of which are topped with fresh toppings.

    In addition, we offer subs and sandwiches, salads, calzone and wraps, our immensely popular buffalo wings, pasta entrees, desserts and a kids' menu.

  • Enzos Pizza and Grill

    In 2014 and 2016, Enzo's was voted Best Pizza in Panama City by Panama City Living Magazine. Also, since opening in 2010, Enzo's has consistently been voted in the Best of Bay's Top Ten for Pizza and in 2015 was in the Top Three for Best of Bay.